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P53 Tumour suppressor protein p53 has different functions that ar related to maintaining genomic stability and inhibiting cell proliferation in response to DNA damage. For preventing neoplasia to occur, the well-nig important of these functions are surcease of cell emergence and induction of either apoptosis surgery senescence.Author: L Ottria, Candotto, F Cura, L Baggi, Hundred Arcuri, M Nardone, RM Gaudio, R Gatto, F Spadari, F CarinciCited by: Publish Year: 2018
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The most important function of mdm2 is to control p53 activity; it is in fact the best documented negative regulator of p53.
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We conducted a medline based literature review concerning the fundamental mechanisms of p53 and its role in the management of bladder cancer.
P53 pathway
This image illustrates P53 pathway.
Keywords used were: 'brca' or 'palb2' operating theater 'tp53' and 'surgery'.
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The objective of this review is to determine whether the p53 tumour suppressor gene plays a role stylish the development of head and cervix cancer.
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Tp53 biomarker
This image representes Tp53 biomarker.
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The maximum date for articles was Apr 2018.
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Clinical trials for tp53 mutation
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Purpose: to assess the p53 protein grammatical construction in pterygial tissue paper and to brushup all immunohistochemical studies on pterygium from medline to valuate the roles of age, gender, raceway, p53 antibody, crosscut levels of immunohistochemical analysis, parts of pterygium, p53 cistron mutation spectrum, and primary or continual pterygium on the p53 staining results.
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Many divers cellular events, including dna damage and hypoxia, activate the p53 gene.
Mutations fashionable the p53 tumour suppressor gene rich person been shown to be one of the most grassroots genetic abnormalities stylish human cancers, and the published lit also shows this to be the case in capitulum and neck Cancer.
Tp53 gene
This picture representes Tp53 gene.
Results: the p53 factor is a tumour suppressor gene that acts as {}guardian of the genome.
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The about important function of mdm2 is to control p53 activity; it is stylish fact the better documented.
A systematic lit search was performed using pubmed, cochrane library, science absolute, and the cyberspace search, with linguistic communication restricted to European country.
Tp53 vus
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We relied on peer-reviewed articles and enclosed literature from the last 10 days written in the english language.
Double microscopic clone 2, placed at 12q15, is an oncogene that codes for Associate in Nursing oncoprotein of which the association with p53 was observed 30 years ago.
Mdm2 amplified sarcomas: letter a literature review.
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Tp53 mutation prognosis
This image demonstrates Tp53 mutation prognosis.
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P53: the gene that cracked the Crab code tells the story of the discovery of the gene and of medical science's charge to unravel its mysteries and acquire to the warmheartedness of what happens in our cells when they number cancerous.
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} many another diverse cellular events, including dna equipment casualty and hypoxia, aerate the p53 gene.
Review of the lit indicates that p53 acts primarily equally a transcription broker whose function is subject to A complex and divers array of valence post‐translational modifications that markedly influence the expression of p53 target genes prudent for cellular responses such as outgrowth arrest, senescence, operating room apoptosis.
What is the p53 gene
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We included studies akin to topics ' accelerated aging expected to cancer', telomerase's relation to ageing and cancer, p53's relation to ageing and cancer, coronary artery disease and cancer from search databases similar pubmed and Google scholar.
Not surprisingly, p53 is the near studied single cistron in history.
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The p53 tumour suppressor has been studied for decades, and still at that place are many questions left unanswered.
A lit review was cooked on pubmed connected surgery in inheritable breast and female internal reproductive organ cancer syndrome.
Last Update: Oct 2021
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Comments
Essence
22.10.2021 03:41
Fashionable this review, we first describe the current understanding of the wild-type p53 functions that find out cell survival OR death, and standard of the protein, with a careful focus on the negative regulators, the murine double microscopical family of proteins.
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22.10.2021 12:22
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Murine bivalent minute clone 2, located at 12q15, is an transforming gene that codes for an oncoprotein of which the tie with p53 was discovered 30 days ago.
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27.10.2021 02:26
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The p53 gene is a tumor suppresser gene that Acts as guardian of the genome.
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25.10.2021 12:08
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Mutations of the neoplasm suppressor gene p53 represent the nigh frequent genetic alteration in human cancers.
Chevelle
24.10.2021 07:47
Materials and methods: we conducted a MEDLINE based literature brushup concerning the important mechanisms of p53 and its part in the direction of bladder cancer.
The search included publicised studies which dealt with detection methods of hpv-related buccal and oropharyngeal cancers and biomolecular studies, particularly regarding the compromising of p53.
This image demonstrates literature review p53.
This image illustrates P53 pathway.
This image representes Tp53 biomarker.
This picture representes Clinical trials for tp53 mutation.
This picture representes Tp53 gene.
This picture demonstrates Tp53 vus.
This image demonstrates Tp53 mutation prognosis.
This picture illustrates What is the p53 gene.